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Hvis person har smerter under aktivitet og belastning, skal gentleman under alle omstændigheder behandles med en korttidsvirkende morfin, som person skal tage efter behov.I LAR inngår legemidler som del av et helhetlig rehabiliteringsforløp. I Norge er to alternativer godkjente for bruk i LAR: Buprenorfin eller metadon, hvorav buprenorfin er det
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